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Graphene films irradiated with safe low-power NIR-emitting diodes kill multidrug resistant bacteria
- Source :
- Carbon. 180:10-21
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Bacterial adhesion to surfaces is the onset of biofilm formation and a hard problem to tackle, aggravated by the rise in drug-resistant bacteria, responsible for more than 500 000 deaths globally/year. This work reports few-layer graphene (FLG) and few-layer graphene oxide (FLGO) as stand-alone light-responsive platforms to develop smart antibacterial surfaces. Films exposure to low-intensity NIR drastically improve their ability to kill planktonic (up to ∼99%) and adherent (up to ∼85%) methicillin-resistant S. aureus and S. epidermidis. Upon irradiation, a mild photothermal effect is observed in supernatant, with temperature rising from 37.0 °C to 39.0 °C–42.0 °C, while surface temperature of non-oxidized FLG films increases to 51.3 °C versus 56.0 °C for oxidized films. Both films prompt total glutathione oxidation when irradiated, despite FLG films induce higher ROS generation than FLGO, suggesting antioxidants depletion occurs preferentially by ROS-dependent pathway (photodynamic effect) for FLG versus ROS-independent pathway for FLGO films. This proof-of-principle study demonstrates that safe, low-intensity NIR irradiation is a valuable and effective tool to boost graphene surfaces’ antibacterial performance through a synergistic photothermal and photodynamic effect. These stand-alone NIR-activated graphene-based platforms arise as simple and economical disinfection surfaces/systems, with widespread use in medical and non-medical applications.
- Subjects :
- Materials science
Graphene
Photothermal effect
Oxide
Biofilm
02 engineering and technology
General Chemistry
Adhesion
Photothermal therapy
010402 general chemistry
021001 nanoscience & nanotechnology
Photochemistry
01 natural sciences
0104 chemical sciences
law.invention
chemistry.chemical_compound
chemistry
law
General Materials Science
Irradiation
0210 nano-technology
Diode
Subjects
Details
- ISSN :
- 00086223
- Volume :
- 180
- Database :
- OpenAIRE
- Journal :
- Carbon
- Accession number :
- edsair.doi...........11c0514e8bc36ac0f80e5d05e6c2c482