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Synthesis and Biological Evaluation of Furano-Epothilone C
- Source :
- Synlett. :1375-1378
- Publication Year :
- 2004
- Publisher :
- Georg Thieme Verlag KG, 2004.
-
Abstract
- An efficient synthesis of furano-epothilone C (1) is described by the use of an aldol reaction and a ring-closing metathesis (RCM) for the closure of the macrocyclic ring system. This new type of analog contains a furan ring in the C8-C10 region of the macrocycle. The biology of this new class of epothilone C analog has been studied.
Details
- ISSN :
- 14372096 and 09365214
- Database :
- OpenAIRE
- Journal :
- Synlett
- Accession number :
- edsair.doi...........11b13f0cc3a12812d0e85622a9d958b6
- Full Text :
- https://doi.org/10.1055/s-2004-829071