Aroyl group driven [1,2] phosphonate-phosphate/phosphine oxide-phosphinate rearrangement

Aroyl group driven phosphonate-phosphate rearrangement in dialkyl/aryl(α-hydroxy-β-oxo-β-arylethyl)phosphonates having α-proton under basic conditions is presented and extended to a novel one-pot direct coupling method between 2-oxoaldehydes (2OA) and H -phosphonates/diphenylphosphine oxide. The one-pot coupling reaction has an advantage in terms of using commercially available substrates and its broad substrate scope. The reactions between 2OAs and diphenylphosphine oxide represent a unique phosphine oxide-phosphinate rearrangement.