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Experimental stand for studying the impact of laser-accelerated protons on biological objects

Authors :
A. M. Sergeev
A. A. Kuzmin
Ivan V. Yakovlev
Shihua Chen
I. A. Shaikin
Andrey Shaykin
Vladislav Ginzburg
A. A. Eremeev
A. A. Soloviev
R. R. Osmanov
A. Sladkov
A V Maslennikova
M. V. Starodubtsev
N I Ignatova
Efim A. Khazanov
Julien Fuchs
K. F. Burdonov
G. Revet
Source :
Quantum Electronics. 46:283-287
Publication Year :
2016
Publisher :
IOP Publishing, 2016.

Abstract

An original experimental stand is presented, aimed at studying the impact of high-energy protons, produced by the laser-plasma interaction at a petawatt power level, on biological objects. In the course of pilot experiments with the energy of laser-accelerated protons up to 25 MeV, the possibility is demonstrated of transferring doses up to 10 Gy to the object of study in a single shot with the magnetic separation of protons from parasitic X-ray radiation and fast electrons. The technique of irradiating the cell culture HeLa Kyoto and measuring the fraction of survived cells is developed. The ways of optimising the parameters of proton beams and the suitable methods of their separation with respect to energy and transporting to the studied living objects are discussed. The construction of the stand is intended for the improvement of laser technologies for hadron therapy of malignant neoplasms.

Details

ISSN :
14684799 and 10637818
Volume :
46
Database :
OpenAIRE
Journal :
Quantum Electronics
Accession number :
edsair.doi...........1176cf05d5d6abaf35d59ce02ed09a8f
Full Text :
https://doi.org/10.1070/qel16043