Compared with placebo, trimethoprim-sulfamethoxazole does not reduce rates of treatment failure after drainage of uncomplicated skin abscesses, but reduces the occurrence of new lesions in the following 30 days

Commentary on: GR Schmitz, D Bruner, R Pitotti, et al.. Randomized controlled trial of trimethoprim–sulfamethoxazole for uncomplicated skin abscesses in patients at risk for community-associated methicillin-resistant Staphylococcus aureus infection.Ann Emerg Med. 2010;56:283–7.