Novel non-squalenoid photoaffinity labels for mammalian squalene epoxidase

Specific affinity labeling of the squalene binding site of squalene epoxidase remains an elusive goal. We wish to report here the design and synthesis of six novel, non-squalenoid, photoaffinity labels for squalene epoxidase, based on the potent inhibitor NB-598 ( 3 ).