A continuous flow investigation of sulfonyl chloride synthesis using N-chloroamides: optimization, kinetics and mechanism

Authors :: Dominik Polterauer
Dominique M. Roberge
Paul Hanselmann
Ryan Littich
Christopher A. Hone
C. Oliver Kappe
Source :: Reaction Chemistry & Engineering. 7:2582-2592
Publication Year :: 2022
Publisher :: Royal Society of Chemistry (RSC), 2022.
Abstract: We develop a continuous flow protocol for the synthesis of sulfonyl chlorides from disulfides and thiols, using 1,3-dichloro-5,5-dimethylhydantoin (DCH) as a dual-function reagent for oxidative chlorination.

Subjects :: Fluid Flow and Transfer Processes
Chemistry (miscellaneous)
Process Chemistry and Technology
Chemical Engineering (miscellaneous)
Catalysis

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