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Evaluation of Antimicrobial and Antioxidant Potential of Essential Oil from Croton piauhiensis Müll. Arg
- Source :
- Current Microbiology. 78:1926-1938
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- A large number of infections are caused by Gram-positive and Gram-negative multi-resistant bacteria worldwide, adding up to a figure of around 700,000 deaths per year. The indiscriminate uses of antibiotics, as well as their misuse, resulted in the selection of bacteria resistant to known antibiotics, for which it has little or no treatment. In this way, the strategies to combat the resistance of microorganisms are extremely important and, essential oils of Croton species have been extensively studied for this purpose. The aim of this study was to carry the evaluation of antibacterial, antibiofilm, antioxidant activities, and spectroscopic investigation of essential oil from Croton piauhiensis (EOCp). The EOCp exhibited antimicrobial activity against Gram-positive and Gram-negative bacteria with required MICs ranging from 0.15 to 5% (v/v). In addition, the MBC of the EOCp for Staphylococcus aureus ATCC 25923 and ATCC 700698, were 0.15 and 1.25%, respectively. Moreover, the EOCp significantly reduced significantly the biofilm production and the number of viable cells from the biofilm of all bacterial strains tested. The antioxidant potential of the EOCp showed EC50 values ranging from 171.21 to 4623.83 μg/mL. The EOCp caused hemolysis (>45%) at the higher concentrations tested (1.25 to 5%), and minor hemolysis (17.6%) at a concentration of 0.07%. In addition, docking studies indicated d-limonene as a phytochemical with potential for antimicrobial activity. This study indicated that the EOCp may be a potential agent against infections caused by bacterial biofilms, and act as a protective agent against ROS and oxidative stress.
- Subjects :
- 0303 health sciences
biology
030306 microbiology
medicine.drug_class
Antibiotics
Biofilm
General Medicine
medicine.disease_cause
biology.organism_classification
medicine.disease
Antimicrobial
Applied Microbiology and Biotechnology
Microbiology
Croton
Hemolysis
law.invention
03 medical and health sciences
Staphylococcus aureus
law
medicine
Bacteria
Essential oil
030304 developmental biology
Subjects
Details
- ISSN :
- 14320991 and 03438651
- Volume :
- 78
- Database :
- OpenAIRE
- Journal :
- Current Microbiology
- Accession number :
- edsair.doi...........1106565caab34a82b384ed1128e6b814