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The role of endocannabinoids in consolidation, retrieval, reconsolidation, and extinction of fear memory
- Source :
- Pharmacological Reports. 73:984-1003
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Endocannabinoids are involved in various physiological functions, including synaptic plasticity and memory, and some psychiatric disorders, such as posttraumatic stress disorder (PTSD), through the activation of cannabinoid (CB) receptors. Patients with PTSD often show excessive fear memory and impairment of fear extinction (FE). It has been reported that the stability of acquired fear memory is altered through multiple memory stages, such as consolidation and reconsolidation. FE also affects the stability of fear memory. Each stage of fear memory formation and FE are regulated by different molecular mechanisms, including the CB system. However, to the best of our knowledge, no review summarizes the role of the CB system during each stage of fear memory formation and FE. In this review, we summarize the roles of endocannabinoids in fear memory formation and FE. Moreover, based on the summary, we propose a new hypothesis for the role of endocannabinoids in fear regulation, and discuss treatment for PTSD using CB system-related drugs.
- Subjects :
- Pharmacology
Fear memory
medicine.medical_treatment
General Medicine
Extinction (psychology)
Endocannabinoid system
03 medical and health sciences
Posttraumatic stress
0302 clinical medicine
030220 oncology & carcinogenesis
Synaptic plasticity
medicine
Memory consolidation
Cannabinoid
Psychology
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 22995684 and 17341140
- Volume :
- 73
- Database :
- OpenAIRE
- Journal :
- Pharmacological Reports
- Accession number :
- edsair.doi...........105ef30a3b02cd68f0407bfcf85089b0