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Evaluating and interpreting bile duct changes in liver allograft biopsies
- Source :
- Diagnostic Histopathology. 18:86-93
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Despite great advances in treatment of liver disease, liver transplant remains the only cure for end stage liver disease and hepatocellular carcinoma. Successful management of immediate and intermediate post-transplant events determines the overall graft outcome, and pathologists play a key role in achieving long-term graft survival. In evaluating liver allograft biopsies, bile duct changes frequently pose diagnostic dilemma as they could occur in association with or the result of various causes of graft dysfunction, but in which accurate classification and interpretation is key to subsequent management. The approach to interpreting these changes share some similarity to the non-transplant liver biopsy interpretation but several additional factors come into play in transplant setting sometimes making interpretation more complex. This review describes bile duct changes occurring in association with various clinical entities in liver allografts, such as acute and chronic rejection, obstruction, small-for-size syndrome, recurrent biliary diseases, and recurrent fibrosing cholestatic hepatitis C, and others, and discusses an approach to interpreting and reporting them.
- Subjects :
- Pathology
medicine.medical_specialty
Graft dysfunction
Histology
medicine.diagnostic_test
Bile duct
business.industry
End stage liver disease
Diagnostic dilemma
medicine.disease
Gastroenterology
Pathology and Forensic Medicine
Liver disease
surgical procedures, operative
medicine.anatomical_structure
Cholestatic hepatitis
Liver biopsy
Hepatocellular carcinoma
Internal medicine
medicine
business
Subjects
Details
- ISSN :
- 17562317
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Diagnostic Histopathology
- Accession number :
- edsair.doi...........0fa4c61792062947aabcbdef0922d3af