Back to Search
Start Over
Programmed Cell Death as a Therapeutic Approach
- Source :
- Wiley Encyclopedia of Chemical Biology
- Publication Year :
- 2008
- Publisher :
- John Wiley & Sons, Inc., 2008.
-
Abstract
- Although turnover rate varies greatly with cell type, the survival of multicellular organisms requires the constant renewal of healthy cells and the removal of pathogen-infected or damaged cells. A critical component of homeostasis is the proper regulation of programmed cell death or apoptosis. Both oversensitivity of crucial cells and resistance of malfunctioning cells to apoptotic stimuli threaten survival. A lack of death response permits mutant cells to survive normal death stimuli and potentially proliferate. Conversely, excess apoptosis removes cells required for organism survival. Restoring homeostasis by controlling apoptosis is a potentially powerful technique for alleviating disease.
Details
- Database :
- OpenAIRE
- Journal :
- Wiley Encyclopedia of Chemical Biology
- Accession number :
- edsair.doi...........0f9647953203dc481f9a6074e6190878