967. Angiotensinogen Inhibits Growth and Angiogenesis of Human Mammary Carcinoma and Prevents Pulmonary Metastasis of Murine Melanoma Cancer

It is now well established that a solid tumor cannot grow beyond a volume of a few mm3 without the formation of new capillaries to supply tumor cells with nutrients and oxygen, and to allow removal of waste products. We have already shown that recombinant human angiotensinogen (AGT) can inhibit endothelial cell proliferation and migration, capillary-like tube formation, and neovascularisation of the chick chorioallantoic membrane1. In order to determine whether these anti-angiogenic activities could impact tumor growth, we have delivered AGT by gene transfer into mice bearing experimental tumors using a replication defective adenovirus (AdAGT).