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Copper-Catalyzed Aerobic Oxidative C(aryl)OH Bond Functionalization of Catechols with Amines Affording Benzoxazoles
- Source :
- Advanced Synthesis & Catalysis. 357:2924-2930
- Publication Year :
- 2015
- Publisher :
- Wiley, 2015.
-
Abstract
- The first copper-catalyzed aerobic oxidative C(aryl)OH bond functionalization of catechols is reported. Under air, at room temperature, in the presence of a copper catalyst, catechols react with amines to produce the corresponding benzoxazoles in high yields. Mechanistic studies suggest that the reaction proceeds via an intriguing competitive oxidation and a synergetic catalysis between catechol and amine.
Details
- ISSN :
- 16154150
- Volume :
- 357
- Database :
- OpenAIRE
- Journal :
- Advanced Synthesis & Catalysis
- Accession number :
- edsair.doi...........0f63396d5db85dcd0132229d06ca0589