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Dendronized mesoporous silica nanoparticles provide an internal endosomal escape mechanism for successful cytosolic drug release
- Source :
- Microporous and Mesoporous Materials. 227:242-251
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Mesoporous silica nanoparticles (MSNs) attract increasing interest in the field of gene and drug delivery due to their versatile features as a multifunctional drug delivery platform. Here, we describe poly(amidoamine) (PAMAM) dendron-functionalized MSNs that fulfill key prerequisites for a controllable intracellular drug release. In addition to high loading capacity, they offer 1) low cytotoxicity, showing no impact on the metabolism of endothelial cells, 2) specific cancer cell targeting due to receptor-mediated cell uptake, 3) a redox-driven cleavage of disulfide bridges allowing for stimuli-responsive cargo release, and most importantly, 4) a specific internal trigger based on the high buffering capacity of PAMAM dendrons to provide endosomal escape.
- Subjects :
- Chemistry
Endosome
Nanoparticle
02 engineering and technology
General Chemistry
Mesoporous silica
010402 general chemistry
021001 nanoscience & nanotechnology
Condensed Matter Physics
01 natural sciences
0104 chemical sciences
Cytosol
Mechanics of Materials
Cancer cell
Drug delivery
Biophysics
General Materials Science
0210 nano-technology
Cytotoxicity
Intracellular
Subjects
Details
- ISSN :
- 13871811
- Volume :
- 227
- Database :
- OpenAIRE
- Journal :
- Microporous and Mesoporous Materials
- Accession number :
- edsair.doi...........0f3361016331099363397ab69777479a