Back to Search
Start Over
Sensorineural hearing loss caused by mitochondrial dna mutations
- Source :
- Journal of Communication Disorders. 31:423-435
- Publication Year :
- 1998
- Publisher :
- Elsevier BV, 1998.
-
Abstract
- Mutations in mitochondrial DNA, which are maternally inherited, have been thought to be one of the causes of sensorineural hearing loss. Two mitochondrial mutational sites (A1555G, A7445G) have been reported to be responsible for non-syndromic hearing impairments. The A1555G mutation causes increased susceptibility to aminoglycoside antibiotic-induced hearing loss as well as non-syndromic sensorineural hearing loss. Our wide screening study showed that there may be a great number of subjects within the Japanese population who have the A1555G mutation. Recent reports suggest that high-risk populations may exist throughout the world. The aminoglycoside-induced hearing loss associated with a mitochondrial mutation is commonly bilateral, symmetric, high frequency involved, and is sometimes associated with progressive sensorineural hearing loss.
- Subjects :
- A1555g mutation
Genetics
Linguistics and Language
medicine.medical_specialty
Mitochondrial DNA
medicine.diagnostic_test
Hearing loss
Cognitive Neuroscience
Experimental and Cognitive Psychology
Audiology
LPN and LVN
medicine.disease
Genetic determinism
Speech and Hearing
DNA Mutational Analysis
Mutation (genetic algorithm)
otorhinolaryngologic diseases
medicine
Sensorineural hearing loss
medicine.symptom
Psychology
Genetic testing
Subjects
Details
- ISSN :
- 00219924
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Journal of Communication Disorders
- Accession number :
- edsair.doi...........0efc49590aad482b94710abd5a51a09a