Quartz Crystal Microbalance–Based Sensors

Quartz crystal microbalance (QCM) sensing with high detection sensitivity has been extensively used together with a specific recognition biomolecule for the analysis of disease biomarkers, clinically relevant analytes, pathogens, environmental pollutants, and food contaminants. Many prospective bioanalytical applications at point-of-care settings have been advocated and proven by this sensing approach. This chapter provides an overview of the QCM sensing and its principle of operation together with numerous immunodiagnostic applications. The technical challenges and future prospects in this field are also discussed.