Synthesis of Gd-DTPA-cholesterol: a new lipophilic gadolinium complex as a potential MRI contrast agent

Authors :: Luciano Lattuada
Giovanna Lux
Source :: Tetrahedron Letters. 44:3893-3895
Publication Year :: 2003
Publisher :: Elsevier BV, 2003.
Abstract: A straightforward and efficient synthesis of Gd-DTPA-cholesterol is reported. This new lipophilic gadolinium complex can be easily incorporated into mixed micelles in order to achieve MRI contrast agents with increased relaxivity. These supramolecular systems can find potential application in magnetic resonance angiography (MRA).

Subjects :: medicine.diagnostic_test
Cholesterol
Gadolinium
MRI contrast agent
fungi
Organic Chemistry
Supramolecular chemistry
food and beverages
chemistry.chemical_element
Biochemistry
Micelle
Magnetic resonance angiography
chemistry.chemical_compound
Nuclear magnetic resonance
chemistry
Drug Discovery
cardiovascular system
medicine
cardiovascular diseases

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