Back to Search
Start Over
Non-neuronal acetylcholine release and its contribution to COPD pathology
- Source :
- Drug Discovery Today: Disease Mechanisms. 3:47-52
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- Chronic obstructive pulmonary disease (COPD) is mainly characterized by airflow limitation and abnormal inflammatory responses. These characteristics can be mimicked by excessive acetylcholine (ACh), the transmitter of parasympathetic axons, and anticholinergic treatment improves airflow in COPD patients. Recently, several non-neuronal sources of ACh have been identified and their release mechanisms differ from that of neurons. This non-neuronal ACh is an important candidate to contribute to COPD pathology, particularly in those regions of the lung that are spared by nerves.
- Subjects :
- Pathology
medicine.medical_specialty
COPD
Lung
medicine.drug_class
business.industry
Copd patients
Pulmonary disease
respiratory system
medicine.disease
respiratory tract diseases
Non neuronal acetylcholine
medicine.anatomical_structure
nervous system
Anesthesia
Drug Discovery
medicine
Anticholinergic
Molecular Medicine
business
Acetylcholine
medicine.drug
Subjects
Details
- ISSN :
- 17406765
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Drug Discovery Today: Disease Mechanisms
- Accession number :
- edsair.doi...........0ed24ea1a1b73feee384ce9377daa7c2