Comparison Of The Prevalence Of Helicobacter Pylori Infection in Patients With Ulcerative Colitis Versus Normal Egyptian population

Background The prevalence of inflammatory bowels diseases (IBD) increases in societies adapting a Western life style. Thus, it appears that there is an inverse relation between the prevalence of IBD and H. Pylori infection. Aim To compare the prevalence of H. Pylori Ag in stool between Ulcerative colitis patients and a normal healthy Egyptian sample. Patients and methods The current study was conducted on 70 patients recruited from the IBD study group clinic in Tropical medicine department of Ain Shams University Hospitals .This study group was compared to historical Control samples of healthy Egyptian subjects who were retrieved from a previously conducted study (saad et al.,2008). The enrolled patients fulfilled the inclusion and exclusion criteria and were divided to two groups o Study group: All patients who were diagnosed with U.C. based on clinical history, laboratory and endoscopic finding according to ECCO 2017 guidelines (Sandro et al., 2017). o Control group: Historical Control samples from healthy Egyptian subjects. Both groups were compared according to basal epidemiologic data and H. pylori Ag in stool positivity, gastrointestinal symptoms, colonscopic and microscopic findings, mainstay treatment lines of U.C., biological therapy and criteria of disease activity . Results Most of the enrolled patients in the current study were aged between 20-39 years with 48.6% aging between 20-29 years old and 38.6% between 30-39 years. While the majority of the cases were females (62.9%), only 11.4% of the included cases were smokers . We found that of the 70 patients in the cases group with ulcerative colitis, only 34 (48.6%) had positive H. pylori versus 555 reported positive samples in control group (91.7%). So there was a high significant statistical difference between the 2 groups Conclusion There is a significant association between H. pylori infection and ulcerative colitis that supports a possible protective benefit of H. pylori infection against the development of U.C. but still further studies are needed