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Adult height in patients with childhood-onset inflammatory bowel disease: a nationwide population-based cohort study
- Source :
- Alimentary Pharmacology & Therapeutics. 51:789-800
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Background Growth retardation is well described in childhood-onset inflammatory bowel disease (IBD). Aims To study if childhood-onset IBD is associated with reduced final adult height. Methods We identified 4201 individuals diagnosed with childhood-onset IBD 1990-2014 (Crohn's disease: n = 1640; ulcerative colitis: n = 2201 and IBD-unclassified = 360) in the Swedish National Patient Register. Results Patients with IBD attained a lower adult height compared to reference individuals (adjusted mean height difference [AMHD] -0.9 cm [95% CI -1.1 to -0.7]) and to their healthy siblings (AMHD -0.8 cm [-1.0 to -0.6]). Patients with Crohn's disease (CD) were slightly shorter than patients with ulcerative colitis (UC; -1.3 cm vs -0.6 cm). Lower adult height was more often seen in patients with pre-pubertal disease onset (AMHD -1.6 cm [-2.0 to -1.2]), and in patients with a more severe disease course (AMHD -1.9 cm, [-2.4 to -1.4]). Some 5.0% of CD and 4.3% of UC patients were classified as growth retarded vs 2.5% of matched reference individuals (OR 2.42 [95% CI 1.85-3.17] and 1.74 [1.36-2.22] respectively). Conclusion Patients with childhood-onset IBD on average attain a slightly lower adult height than their healthy peers. Adult height was more reduced in patients with pre-pubertal onset of disease and in those with a more severe disease course.
- Subjects :
- medicine.medical_specialty
Hepatology
business.industry
Gastroenterology
Case-control study
Disease
medicine.disease
Inflammatory bowel disease
Ulcerative colitis
digestive system diseases
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
030211 gastroenterology & hepatology
Pharmacology (medical)
030212 general & internal medicine
Young adult
Age of onset
Colitis
business
Cohort study
Subjects
Details
- ISSN :
- 02692813
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Alimentary Pharmacology & Therapeutics
- Accession number :
- edsair.doi...........0ea167ec84b38212875283687d63b811