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The role of coagulation abnormalities in the development of Perthes’ disease
- Source :
- The Journal of Bone and Joint Surgery. British volume. :744-746
- Publication Year :
- 2000
- Publisher :
- British Editorial Society of Bone & Joint Surgery, 2000.
-
Abstract
- Recent reports have suggested an association between Perthes’ disease and an underlying thrombophilic or hypofibrinolytic tendency. In Northern Ireland there is a high incidence of Perthes’ disease (11.7 per 100 000 or 1 in 607 children) in a stable paediatric population. We reviewed 139 children with Perthes’ disease and compared them with a control group of 220 aged- and gender-matched healthy primary schoolchildren with similar racial and ethnic backgrounds. There were no significant deficiencies of antithrombotic factors protein C, protein S, antithrombin III or resistance to activated protein C. A total of 53 (38.1%) of the children with Perthes’ disease had a prolonged activated partial thromboplastin time (> 38) compared with 13 (5.9%) of the control group (p < 0.001). Our findings have shown that using standard assays, thrombophilia secondary to antithrombotic factor deficiency or resistance to activated protein does not appear to be an aetiological factor for Perthes’ disease. The cause of the prolonged activated partial thromboplastin time, usually associated with a clotting factor deficiency, is under further investigation.
- Subjects :
- medicine.medical_specialty
medicine.diagnostic_test
Bone disease
business.industry
Incidence (epidemiology)
Antithrombin
Disease
medicine.disease
Surgery
Pathogenesis
Internal medicine
Antithrombotic
Epidemiology
medicine
Orthopedics and Sports Medicine
business
Partial thromboplastin time
medicine.drug
Subjects
Details
- ISSN :
- 20445377 and 0301620X
- Database :
- OpenAIRE
- Journal :
- The Journal of Bone and Joint Surgery. British volume
- Accession number :
- edsair.doi...........0e61e84a7aee9eddc002d78141c856d1