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RETRACTED: Vitamin D receptor (VDR) promoter targeting through a novel chromatin remodeling complex
- Source :
- The Journal of Steroid Biochemistry and Molecular Biology. :173-178
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- We have purified nuclear complexes for Vitamin D receptor (VDR), and identified one of them as a novel ATP-dependent chromatine remodeling containing Williams syndrome transcription factor (WSTF), that is supposed to be responsible for Williams syndrome. This complex (WSTF including nucleosome assembly complex (WINAC)) exhibited an ATP-dependent chromatin remodeling activity in vitro. Transient expression assays revealed that WINAC potentiates ligand-induced function of VDR in gene activation and repression. Thus, this study describes a molecular basis of the VDR function on chromosomal DNA through chromatine remodeling.
- Subjects :
- Regulation of gene expression
biology
Nucleosome assembly
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Promoter
Cell Biology
Histone acetyltransferase
Biochemistry
Molecular biology
Calcitriol receptor
Chromatin remodeling
Chromatin
Endocrinology
biology.protein
Molecular Medicine
Molecular Biology
Psychological repression
Subjects
Details
- ISSN :
- 09600760
- Database :
- OpenAIRE
- Journal :
- The Journal of Steroid Biochemistry and Molecular Biology
- Accession number :
- edsair.doi...........0e51f5e710da2956f360f0af082954b4