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The relationship of genetic aberrations detected by comparative genomic hybridization to DNA ploidy and tumor size in human oral squamous cell carcinomas
- Source :
- Journal of Oral Pathology & Medicine. 29:226-231
- Publication Year :
- 2000
- Publisher :
- Wiley, 2000.
-
Abstract
- We have examined genetic alterations in 11 surgically removed oral squamous cell carcinomas (OSCCs) using comparative genomic hybridization (CGH) and laser scanning cytometry (LSC), which allow quantitative analysis of chromosomal abnormalities. CGH analysis revealed gains and/or losses of DNA sequence copy number in all tumors. Gains in DNA sequence copy number were detected frequently for chromosome arms 3q25-28 (6/11), 5p (6/11) and 8q (5/11), and losses in chromosome arms 18q (4/11), 19q (4/11), 17p (3/11), and 19p (3/11). Amplification of 5p was observed in two tumors. LSC detected DNA aneuploidy with DNA indices ranging from 1.30 to 1.82 in 6 of 11 tumors. The number of chromosomal aberrations was higher in DNA aneuploid tumors than in diploid tumors (8.17 vs 3.60/tumor, P
- Subjects :
- Cancer Research
medicine.diagnostic_test
Chromosome
Biology
Molecular biology
DNA sequencing
Pathology and Forensic Medicine
chemistry.chemical_compound
Otorhinolaryngology
Epidermoid carcinoma
chemistry
Chromosome instability
Biopsy
medicine
Periodontics
Oral Surgery
Ploidy
DNA
Comparative genomic hybridization
Subjects
Details
- ISSN :
- 09042512
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Journal of Oral Pathology & Medicine
- Accession number :
- edsair.doi...........0dff9ee61dbf24b83115a394b8c53cf5