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Drug targets modulating the gut-appetite-metabolism axis
- Source :
- Drug Discovery Today: Therapeutic Strategies. 4:189-193
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- Gut peptides and their receptors are becoming of more interest as possible drug targets because the physiological role of these peptides is becoming increasingly clear. The glucagon-like peptides have physiological roles in glucose homeostasis, appetite regulation and intestinal proliferation. The PP family similarly plays a role in appetite regulation, thus making these peptides a possible target for the treatment of obesity and metabolic disease. Ghrelin, in contrast to the previously mentioned peptides stimulates appetite and gut motility, making it a target for drugs improving gut motility.
Details
- ISSN :
- 17406773
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Drug Discovery Today: Therapeutic Strategies
- Accession number :
- edsair.doi...........0dd7e0c973587be8e1b3a92e7139b46c