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Retrograde intra-arterial chemotherapy and daily concurrent proton beam therapy for recurrent oral cavity squamous cell carcinoma: Analysis of therapeutic results in 46 cases
- Source :
- Head & Neck. 38:1145-1151
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Background The purpose of this study was to evaluate the efficacy and toxicities of proton beam therapy combined with intra-arterial infusion chemotherapy via superficial temporal and occipital arteries for recurrent oral cavity squamous cell carcinoma (SCC). Methods Between October 2009 and June 2013, 46 patients with recurrent oral cavity SCC were treated by proton beam therapy combined with intra-arterial infusion chemotherapy of cisplatin (CDDP) and docetaxel. Treatment consisted of proton beam therapy (28.6–74.8 GyE in 13–34 fractions) and intra-arterial infusion chemotherapy (CDDP, 30–50 mg/body/week; docetaxel, 5–25 mg/body/week). Results One-year and 2-year overall survival (OS) rates were 65% and 46%, respectively. One-year and 2-year local control rates were 81% and 70%, respectively. Conclusion These findings suggest that proton beam therapy combined with intra-arterial infusion chemotherapy could be applied effectively and safely for patients with recurrent oral cavity SCC. © 2016 Wiley Periodicals, Inc. Head Neck, 2016
- Subjects :
- Mouth neoplasm
Cisplatin
medicine.medical_specialty
medicine.diagnostic_test
business.industry
Urology
Retrospective cohort study
030218 nuclear medicine & medical imaging
Surgery
03 medical and health sciences
0302 clinical medicine
Otorhinolaryngology
Docetaxel
Recurrent Oral Cavity Squamous Cell Carcinoma
030220 oncology & carcinogenesis
medicine
business
Proton therapy
Survival analysis
medicine.drug
Computed tomography angiography
Subjects
Details
- ISSN :
- 10433074
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Head & Neck
- Accession number :
- edsair.doi...........0dc8e422cc2a3e5ea1c7148542eaff58