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Anti-proliferative Activities of Two Flavonols with Unsubstituted B-ring from the Leaves of Platanus acerifolia
- Source :
- Natural Product Communications. 12:1934578X1701201
- Publication Year :
- 2017
- Publisher :
- SAGE Publications, 2017.
-
Abstract
- The anti-proliferative activities against five cancer cell lines of two flavonols (1, 2) with unsubstituted B ring isolated from the ethanol extract of the leaves of Platanus acerifolia were investigated. The results showed that compound 1 possessed a noteworthy anti-proliferative activity against MGC-803 cells with an IC50 value of 17.26±1.04 μM, and compound 2 was less active than 1 with an IC50 value of 20.29±1.37 μM compared with 41.94±1.58 μM for the positive control group. In addition, the results of Hoechst 33258 staining, AO/EB staining and annexinV-FITC assays indicated that 1 caused a significant MGC-803 cellular apoptosis in a dose-dependent manner. The further mechanisms showed that compound 1 induced the production of ROS, decreased the mitochondrial membrane potential, and altered pro- and anti-apoptotic proteins, leading to activation of caspase-9 and caspase-3 in the process of cellular apoptosis. The present investigation indicated that compound 1 could be used as a potential anti-cancer candidate.
- Subjects :
- Pharmacology
chemistry.chemical_classification
Chemistry
Stereochemistry
Plant Science
General Medicine
Anti proliferative
Ring (chemistry)
01 natural sciences
0104 chemical sciences
010404 medicinal & biomolecular chemistry
03 medical and health sciences
0302 clinical medicine
Flavonols
Complementary and alternative medicine
030220 oncology & carcinogenesis
Drug Discovery
Platanus acerifolia
Cancer cell lines
Subjects
Details
- ISSN :
- 15559475 and 1934578X
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Natural Product Communications
- Accession number :
- edsair.doi...........0dbf0e78a590d23a8e33bc991eb7d8d4