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Clinicopathological Significance of Large Tumor Suppressor (LATS) Expression in Gastric Cancer
- Source :
- Journal of Gastric Cancer. 17:363
- Publication Year :
- 2017
- Publisher :
- The Korean Gastric Cancer Association, 2017.
-
Abstract
- Purpose The aims of this study were to evaluate the expression of the large tumor suppressor (LATS) genes LATS1 and LATS2 by immunohistochemical staining of gastric cancer, and to evaluate the clinicopathological significance of LATS expression and its correlation with overall survival (OS). Materials and Methods LATS1 and LATS2 expression in a tissue microarray was detected by immunohistochemistry, using 264 gastric cancer specimens surgically resected between July 2006 and December 2009. Results Low expression of LATS1 was significantly associated with more advanced American Joint Committee on Cancer (AJCC) stage (P=0.001) and T stage (P=0.032), lymph node (LN) metastasis (P=0.040), perineural invasion (P=0.042), poor histologic grade (P=0.007), and diffuse-type histology by the Lauren classification (P=0.033). Low expression of LATS2 was significantly correlated with older age (≥65, P=0.027), more advanced AJCC stage (P=0.001) and T stage (P=0.001), LN metastasis (P=0.004), perineural invasion (P=0.004), poor histologic grade (P
- Subjects :
- 0301 basic medicine
Cancer Research
medicine.medical_specialty
Tissue microarray
business.industry
Gastroenterology
Perineural invasion
Cancer
Histology
medicine.disease
Metastasis
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Internal medicine
Medicine
T-stage
business
Lymph node
Survival analysis
Subjects
Details
- ISSN :
- 20935641 and 2093582X
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Journal of Gastric Cancer
- Accession number :
- edsair.doi...........0da16b01403b733b1cabb7f3e0e1ed1e