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Long-term survivor of relapsed stage IV malignant rhabdoid tumor of the kidney
- Source :
- Pediatrics International. 55:245-248
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- The prognosis for metastatic malignant rhabdoid tumor (MRT) is poor, and metastatic (stage IV) MRT was resistant to conventional treatment, with less than 20% of cure rate. Moreover, there have been no reports of patients who have survived relapsed stage IV MRT. Here we report a long-term survivor of relapsed MRT with lung metastasis at diagnosis. He was diagnosed as MRT of the kidney at 5-month-old. After resection of the renal tumor, he was treated with ICE (ifosfamide, carboplatin, and etoposide), total abdominal irradiation 10.8 Gy and high-dose chemotherapy using thiotepa and melphalan. Six months after initial treatment, a relapse in the lung was detected, and he received chemotherapy including doxorubicin/pirarubicin for 78 weeks. He is alive at five years of follow up, without any evidence of disease. Our report suggests the important role of anthracycline in treatment of MRT.
- Subjects :
- Melphalan
Oncology
Chemotherapy
medicine.medical_specialty
Ifosfamide
Anthracycline
business.industry
medicine.medical_treatment
Pirarubicin
ThioTEPA
Carboplatin
chemistry.chemical_compound
chemistry
Internal medicine
Pediatrics, Perinatology and Child Health
medicine
business
Etoposide
medicine.drug
Subjects
Details
- ISSN :
- 13288067
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Pediatrics International
- Accession number :
- edsair.doi...........0d8684005e1aa83fabb66a3b38cd1f00