The Specificity of Interferon Induction

The interferon response may be induced by a variety of nonreplicating polyanionic macromolecules (Ho et al., 1967). Double-stranded RNA from a variety of sources is a potent inducer of interferon (Lampson et al., 1967; Tytell et al., 1967; Field et al., 1967a). The demonstration that double-stranded synthetic polyribonucleotides are also effective interferon inducers (Field et al., 1967b) stimulated the research presented in this paper.