Progestogen hypersensitivity: case report

Progestogen hypersensitivity is characterized by heterogeneous skin eruptions that cyclically aggravate during the luteal phase of the menstrual cycle, corresponding to a rise in progesterone levels. The clinical presentation is highly variable, with urticarial, angioedema, and eczematous lesions being prominent. Both endogenous progesterone and exogenous progestogens may represent an initial trigger. We report the case of a 42-year old woman who was unresponsive to all treatments, including progestin desensitization, that ultimately required bilateral oophorectomy to control her symptoms.