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Oral Calcium Supplements Associate With Serial Coronary Calcification
- Source :
- JACC: Cardiovascular Imaging. 14:259-268
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Objectives This study sought to evaluate and assess the extent of serial coronary artery calcification in response to oral calcium supplementation. Background Oral calcium supplements are frequently used despite their cardiovascular safety remaining controversial. Their effects on serial coronary calcification are not well established. Methods In a post hoc patient-level analysis of 9 prospective randomized trials using serial coronary intravascular ultrasound, changes in serial percentage of atheroma volume (PAV) and calcium indices (CaI) were compared in matched segments of patients coronary artery disease who were receiving concomitant calcium supplements (n = 447) and in those who did not receive supplements (n = 4,700) during an 18- to 24-month trial period. Results Patients (mean age 58 ± 9 years; 73% were men; 43% received concomitant high-intensity statins) demonstrated overall annualized changes in PAV and CaI with a mean of −0.02 ± 1.9% (p = 0.44) and a median of 0.02 (interquartile range: 0.00 to 0.06) (p Conclusions Oral calcium supplementation may increase calcium deposition in the coronary vasculature independent of changes in atheroma volume. The impact of these changes on plaque stability and cardiovascular outcomes requires further investigation.
- Subjects :
- medicine.medical_specialty
chemistry.chemical_element
030204 cardiovascular system & hematology
Calcium
030218 nuclear medicine & medical imaging
law.invention
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
Interquartile range
Internal medicine
Intravascular ultrasound
Medicine
Radiology, Nuclear Medicine and imaging
medicine.diagnostic_test
business.industry
medicine.disease
Atheroma
chemistry
Concomitant
Coronary artery calcification
Cardiology
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 1936878X
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- JACC: Cardiovascular Imaging
- Accession number :
- edsair.doi...........0cf74528c882f5c6b0db932e5c02800e