Tumor-infiltrating lymphocytes in biallelic-CDK12 mutated prostate cancer

Authors :: David Dolling
Johann S. De Bono
Nina Tunariu
Antonella Petremolo
Diletta Bianchini
Mattia Rediti
Claudia Bertan
Pasquale Rescigno
Semini Sumanasuriya
Ana Ferreira
Alec Paschalis
Ruth Riisnaes
Maialen Barrero
Daniel Nava Rodrigues
Mateus Crespo
Robert Chandler
Adam Sharp
Carlo Messina
Suzanne Carreira
Joaquin Mateo
Source :: Journal of Clinical Oncology. 36:5070-5070
Publication Year :: 2018
Publisher :: American Society of Clinical Oncology (ASCO), 2018.
Abstract: 5070Background: Cyclin-dependent kinase 12 (CDK12) mutations have been described in lethal prostate cancer (PCa) and are reported to impact DNA repair including homologous recombination repair, and...

Subjects :: 0301 basic medicine
Cancer Research
Tumor-infiltrating lymphocytes
DNA repair
business.industry
Kinase
medicine.disease
03 medical and health sciences
Prostate cancer
030104 developmental biology
0302 clinical medicine
Oncology
030220 oncology & carcinogenesis
medicine
Cancer research
Homologous recombination
business
CDK12

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