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Discovery of antibacterial agents targeting biofilm formation: total synthesis and in vitro investigation of amycolasporins
- Source :
- Organic & Biomolecular Chemistry. 20:6831-6843
- Publication Year :
- 2022
- Publisher :
- Royal Society of Chemistry (RSC), 2022.
-
Abstract
- The total synthesis of antibacterial amycolasporin A, (±) amycolasporins B and C and their analogues (18, 19, 30a and 30d–30f) was introduced; 30d obviously inhibited bacterial biofilm formation and promoted intracellular ROS release.
- Subjects :
- Organic Chemistry
Physical and Theoretical Chemistry
Biochemistry
Subjects
Details
- ISSN :
- 14770539 and 14770520
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Organic & Biomolecular Chemistry
- Accession number :
- edsair.doi...........0c04c24655fbdc25a175feb014cb9430
- Full Text :
- https://doi.org/10.1039/d2ob01166b