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Preliminary report
- Source :
- Metabolism. 49:1243-1246
- Publication Year :
- 2000
- Publisher :
- Elsevier BV, 2000.
-
Abstract
- Treatment with small doses of subcutaneous insulin is being investigated as a possible approach to prevent type 1 diabetes in humans. The mechanism of prophylactic insulin therapy could involve the inhibition of beta-cell secretory activity and/or the initiation of an active immunoregulatory process. To evaluate the pure metabolic effect of exogenous insulin, the present study assessed whether daily subcutaneous administration of ultralente insulin alters beta-cell function in normal adults. Fourteen healthy adults were randomized to receive 0.2 U/kg x d ultralente insulin (Ultratard; Novo Nordisk, Bagsvaerd, Denmark) or placebo subcutaneously once daily for 30 days. Plasma glucose, C-peptide, and insulin concentrations were measured in the fasting state and 1 hour after a standardized breakfast, during treatment and during a recovery period of 10 days. Insulin administration induced a 15% to 40% decrease of fasting plasma C-peptide. In contrast, postbreakfast plasma C-peptide increased by 40% to 90% in subjects receiving insulin. Fasting and postbreakfast C-peptide concentrations were significantly different between groups during the injection period after adjustment for baseline concentrations (P < .05, ANOVA with repeated measures). These alterations disappeared 3 days after cessation of insulin treatment. The present regimen of exogenous insulin alters endogenous insulin secretion in normal subjects. Instead of the expected beta-cell rest, the effect appeared to be dual, with insulin secretion decreasing in the basal state and increasing after meals.
- Subjects :
- medicine.medical_specialty
Type 1 diabetes
business.industry
C-peptide
Endocrinology, Diabetes and Metabolism
Insulin
medicine.medical_treatment
Repeated measures design
Placebo
medicine.disease
chemistry.chemical_compound
Endocrinology
Postprandial
Basal (medicine)
chemistry
Internal medicine
Blood plasma
medicine
business
Subjects
Details
- ISSN :
- 00260495
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Metabolism
- Accession number :
- edsair.doi...........0babacca44742713cc40fc3b51972fc1