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Alkylation of N-arylcyanamides and electron-deficient phenols with (chloromethyl)thiirane
- Source :
- Chemistry of Heterocyclic Compounds. 47:1509-1515
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- Alkylation of N-arylcyanamides with (chloromethyl)thiirane in aqueous alkaline solution provides an easy synthetic approach to N-aryl-N-(thietan-3-yl)cyanamides. Yields vary from 34 to 76% and are lower in the case of electron-deficient aryl substituents. The reaction with phenols containing electron-withdrawing groups results in formation of 3-(aryloxy)thietanes in 19–45% yields.
Details
- ISSN :
- 15738353 and 00093122
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Chemistry of Heterocyclic Compounds
- Accession number :
- edsair.doi...........0b94c23a2d04ba51b46b356fb154f129