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Carboxymethylchitin Nanocarrier (CMCNC): A Novel Therapeutic Formulation for Drug Release
- Source :
- Polymer-Plastics Technology and Materials. 58:55-69
- Publication Year :
- 2018
- Publisher :
- Informa UK Limited, 2018.
-
Abstract
- In the present work, chitin based derivatives carboxymethylchitin, CMC were synthesised for nanocarriers (NCs). Cu and Fu loaded NCs had also been prepared and characterized by various physiochemical & biological techniques. Here, drug release profiles and drug kinetics were also studied. In vitro cytotoxicity test (Cell Viability-A549 cells) result found most effected. CMCNC also fitted best in Higuchi model which proved that this prepared nanocarriers followed the mechanism of diffusion rather than dissolution and degradation. The overall analysis leads to the conclusion that CMCNC found to be a suitable nanocarrier for targeted drug delivery.
- Subjects :
- Polymers and Plastics
Drug Kinetics
General Chemical Engineering
In vitro cytotoxicity
02 engineering and technology
010402 general chemistry
021001 nanoscience & nanotechnology
Carboxymethylchitin
01 natural sciences
Combinatorial chemistry
0104 chemical sciences
chemistry.chemical_compound
Targeted drug delivery
Chitin
chemistry
Drug delivery
Materials Chemistry
Drug release
Nanocarriers
0210 nano-technology
Subjects
Details
- ISSN :
- 2574089X and 25740881
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Polymer-Plastics Technology and Materials
- Accession number :
- edsair.doi...........0b3e0b9e442037978798e485823c77d2
- Full Text :
- https://doi.org/10.1080/03602559.2018.1466162