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Carboxymethylchitin Nanocarrier (CMCNC): A Novel Therapeutic Formulation for Drug Release

Authors :
Tanvi Jain
P. K. Dutta
Sushil Kumar
Source :
Polymer-Plastics Technology and Materials. 58:55-69
Publication Year :
2018
Publisher :
Informa UK Limited, 2018.

Abstract

In the present work, chitin based derivatives carboxymethylchitin, CMC were synthesised for nanocarriers (NCs). Cu and Fu loaded NCs had also been prepared and characterized by various physiochemical & biological techniques. Here, drug release profiles and drug kinetics were also studied. In vitro cytotoxicity test (Cell Viability-A549 cells) result found most effected. CMCNC also fitted best in Higuchi model which proved that this prepared nanocarriers followed the mechanism of diffusion rather than dissolution and degradation. The overall analysis leads to the conclusion that CMCNC found to be a suitable nanocarrier for targeted drug delivery.

Details

ISSN :
2574089X and 25740881
Volume :
58
Database :
OpenAIRE
Journal :
Polymer-Plastics Technology and Materials
Accession number :
edsair.doi...........0b3e0b9e442037978798e485823c77d2
Full Text :
https://doi.org/10.1080/03602559.2018.1466162