Back to Search
Start Over
PLUNC protein expression in major salivary glands of HIV-infected patients
- Source :
- Oral Diseases. 17:258-264
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- Oral Diseases (2011) 17, 258–264 Objective: To analyse and compare the expression of Palate, Lung, and Nasal Epithelium Clone (PLUNC) proteins in salivary glands from patients with and without AIDS (control group) using autopsy material. Methods: We analysed the expression of PLUNCs using immunohistochemistry in parotid (n = 45), submandibular (n = 47) and sublingual gland (n = 37) samples of AIDS patients [30 with normal histology, 21 with mycobacteriosis, 14 with cytomegalovirus (CMV) infection, 30 with chronic non-specific sialadenitis, and 30 HIV-negative controls. In situ hybridization (ISH) for SPLUNC 2 in the HIV-negative group was performed. Results: SPLUNC 1 expression was detected in the mucous acini of submandibular and sublingual glands, and SPLUNC 2 were seen in the serous cells. LPLUNC 1 expression was only positive in the salivary ducts. There was a higher expression of SPLUNC 2 in AIDS patients with CMV infection and mycobacteriosis when compared with all other groups. The intensity of staining for SPLUNC 2 was greater around the lesions than the peripheral ones. ISH for SPLUNC 2 showed perinuclear positivity in the serous cells in all HIV-negative cases. Conclusions: SPLUNC 1 and LPLUNC 1 proteins were similarly expressed in the salivary glands of AIDS patients and non-HIV patients. CMV infection and mycobacteriosis increase SPLUNC 2 expression in serous cells in the salivary gland of AIDS patients.
- Subjects :
- Pathology
medicine.medical_specialty
Salivary gland
virus diseases
Sublingual gland
Plunc
Biology
medicine.disease
Submandibular gland
Sialadenitis
Serous fluid
medicine.anatomical_structure
stomatognathic system
Otorhinolaryngology
Salivary Gland Diseases
Major Salivary Gland
Immunology
medicine
General Dentistry
Subjects
Details
- ISSN :
- 1354523X
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Oral Diseases
- Accession number :
- edsair.doi...........0b3280455f411c3528cb343afb240394