Nuclear Medicine in Neurological and Psychiatric Diagnosis

1. In blood–brain barrier imaging: (a) Longitudinal sinuses reveal a higher tracer uptake than the brain. (b) Transverse sinuses reveal a higher tracer uptake than the brain. (c) Blood–brain barrier imaging is performed by 99m-pertechnetate, 99mTc-DTPA, and 99mTc-glucoheptonate. (d) All of the above. 2. Which of the following is NOT a characteristic of the blood–brain barrier (BBB)? (a) High ionic permeability. (b) Existence of Na/K pump. (c) Low nonelectrolyte hydrophilic permeability. (d) It is a tight connection of endothelial cells. 3. Which of the following is a determinant of the transport of lipophilic agents from the blood–brain barrier (BBB)? (a) Na/K pump. (b) Calcium pump. (c) Glycoprotein pump. (d) The cerebral entry of lipophilic agents occurs without any intervention. 4. Which of the following factors is the least important in the permeability of the blood–brain barrier? (a) Lipophilicity. (b) Osmotic pressure. (c) Protein binding. (d) Hydrostatic pressure. 5. Which of the following patterns of BBB imaging in neonates with asphyxia indicates high brain involvement? (a) Typical stroke pattern of uptake in one of the large cerebral arteries. (b) Abnormal uptake in the intermediary region of large cerebral arteries. (c) Skull cap-like increase in uptake. (d) Abnormal focal uptake in the basal ganglia.