A comprehensive review on pyrimidine analogs-versatile scaffold with medicinal and biological potential

Pyrimidines are nitrogen-containing heterocycles known for anticancer, anti-HIV, antifungal, and antibacterial activities. Pyrimidines, compounds bearing this heterocycle, are common in many medicinal drugs. Based on these findings, we have also reported the synthesis and biological activities of potential pyrimidine analogs. This review article provides a comprehensive insight into clinically approved pyrimidine-containing drugs and recent reports based on the broad-spectrum activities of pyrimidine analogs. Further, this review highlights the main aspects of pyrimidine analogs such as anticancer, sedative, antibiotic, antiviral, anti-inflammatory, analgesics, and anti-microbial activities, that make this molecule a more attractive scaffold for the discovery of newer drugs.