A phase I, open-label mass balance study of the hedgehog pathway inhibitor (HPI) GDC-0449 in healthy female subjects of non-childbearing potential

Authors :: G. E. Morrison
Bert L. Lum
K. Jorga
Jennifer A. Low
C. Hop
Ilsung Chang
Richard A. Graham
Vikram Malhi
M. Xie
Young G. Shin
Source :: Journal of Clinical Oncology. 28:2558-2558
Publication Year :: 2010
Publisher :: American Society of Clinical Oncology (ASCO), 2010.
Abstract: 2558 Background: In a phase I trial, GDC-0449, a small molecule HPI, was well tolerated in patients (pts) with solid tumors and showed promising efficacy in advanced basal cell carcinoma (Von Hoff ...

Subjects :: Cancer Research
medicine.medical_specialty
Balance study
business.industry
Childbearing Potential
medicine.disease
Small molecule
Hedgehog signaling pathway
stomatognathic diseases
Endocrinology
Oncology
Internal medicine
medicine
Cancer research
Basal cell carcinoma
In patient
Open label
business

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