The Rao–Blackwell theorem in stereology and some counterexamples

A version of the Rao–Blackwell theorem is shown to apply to most, but not all, stereological sampling designs. Estimators based on random test grids typically have larger variance than quadrat estimators; random s-dimensional samples are worse than random r-dimensional samples for s < r. Furthermore, the standard stereological ratio estimators of different dimensions are canonically related to each other by the Rao–Blackwell process. However, there are realistic cases where sampling with a lower-dimensional probe increases efficiency. For example, estimators based on (conditionally) non-randomised test point grids may have smaller variance than quadrat estimators. Relative efficiency is related to issues in geostatistics and the theory of wide-sense stationary random fields. A uniform minimum variance unbiased estimator typically does not exist in our context.