Experimental investigation and modeling of the solubility of carvedilol in supercritical carbon dioxide

This study was aimed to measure the solubility of carvedilol in the temperature and pressure ranges of 308⿿338 K and 160 bar to 400 bar, respectively. In this direction, a homemade high pressure visual equilibrium cell was used to measure the solubility of carvedilol using a static method coupled with gravimetric technique. The results revealed that the carvedilol solubility was ranged between 1.12 y 10⿿5 and 5.01 y 10⿿3 based on the mole fraction (mole of carvedilol/mole of carvedilol + mole of CO2) in this study as the temperature and pressure was changed. Finally, the results were correlated using four density-based semi-empirical correlations including Chrastil, Mendez⿿Santiago⿿Teja (MST), Bartle et al., and Kumar and Johnston (K-J) models. Results revealed that although the K-J model leads to the lowest average absolute relative deviation percent (AARD %) of 6.27%, but it could not be considered as the most accurate correlation since all the used four correlations introduces AARD % of about 6⿿10% which may be in the same range as the experimental error.