Studies on the chemistry of thienoanellatedO,N- andS,N-containing heterocycles.6. Synthesis of some thienoanellated [1,4]benzoxazepines

Substituted thieno[2,3-b][1,4]benzoxazepine derivatives as well as thieno[3,2-b][1,4]benzoxazepine deriva- tives have been synthesized. They are thienoanalogues of loxapine, a potent antipsychotic drug. Research activities concentrate on the preparation of structurally modified compounds of loxapine to minimize its undesirable extrapyramidal symptoms.