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Difficulties in diagnosing atypical variants of Alzheimer’s disease

Authors :
A. A. Tappakhov
T. E. Popova
Natalia Shnayder
T. Ya. Nikolaeva
Source :
Russian neurological journal. 26:16-23
Publication Year :
2021
Publisher :
Medical Informational Agency Publishers, 2021.

Abstract

Alzheimer’s disease (AD) is the most common cause of dementia in the population. Late onset AD has a classic clinical picture with short-term memory deficit, apraxia and agnosia. Patients with early-onset AD may have an atypical clinical picture which complicates diagnosis. Atypical AD variants include the logopenic variant of primary progressive aphasia, posterior cortical atrophy, behavioral, biparietal, and cortico-basal variants. These variants have pathomorphological signs similar to classical AD, but at an early stage they are characterized by focal atrophy which explains their clinical polymorphism. This article provides a review of the current literature on atypical types of AD and presents a clinical case of a 62-year-old patient in whom the disease debuted with prosopagnosia due to focal atrophy of the temporo-occipital regions of the non-dominant hemisphere.

Details

ISSN :
26867192 and 26587947
Volume :
26
Database :
OpenAIRE
Journal :
Russian neurological journal
Accession number :
edsair.doi...........08169ee22a9531c12dcaf5a1d4ff646c
Full Text :
https://doi.org/10.30629/2658-7947-2021-26-5-16-23