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Prognostic Value of Plasma Human Immunodeficiency Virus Type 1 (HIV-l) RNA Levels in Patients with Advanced HIV-l Disease and with Little or No Prior Zidovudine Therapy
- Source :
- Journal of Infectious Diseases. 174:696-703
- Publication Year :
- 1996
- Publisher :
- Oxford University Press (OUP), 1996.
-
Abstract
- The association of plasma human immunodeficiency virus type 1 (HIV-1) RNA level at study entry and over time with clinical progression was evaluated in 187 patients from AIDS Clinical Trials Group protocol 116A who had little or no prior zidovudine treatment. Three-fold-higher HIV-1 RNA levels at study entry and 3-fold increases by week 8 were associated with progression (relative hazard [RH], 1.67 ; 95% confidence limits [CL], 1.20, 2.32 ; and RH, 1.45 ; CL, 1.02, 2.05, respectively). Having 3-fold-higher CD4 cell count at entry was independently associated with a 52% reduction in risk for progression (adjusted RH, 0.48 ; CL, 0.33, 0.70). When stratified by length of prior zidovudine therapy, RNA level was predictive in drug-naive patients (adjusted RH, 1.87 ; CL, 1.23, 2.85) but not predictive in patients with up to 16 weeks of prior therapy (adjusted RH, 1.11 ; CL, 0.70, 1.76). Analysis suggests that the acquisition of mutations at HIV-1 reverse transcriptase codons 215 and 74 is associated with subsequent increases in HIV-1 RNA level (relative risk, 7.00 ; CL, 0.86, 56.90).
- Subjects :
- Oncology
medicine.medical_specialty
business.industry
RNA
medicine.disease
Reverse transcriptase
Virus
Zidovudine
Infectious Diseases
Acquired immunodeficiency syndrome (AIDS)
Relative risk
Internal medicine
Immunopathology
Immunology
medicine
Immunology and Allergy
Risk factor
business
medicine.drug
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 174
- Database :
- OpenAIRE
- Journal :
- Journal of Infectious Diseases
- Accession number :
- edsair.doi...........07b7d142cfc4cbd2aeae0ee0fd8bbe5c