Depressor effect of magnesium lithospermate B, a component of Salviae Miltiorrhizae Radix, in spontaneously hypertensive rats

The effects of magnesium lithospermate B on blood pressure were examined in spontaneously hypertensive rats. Systolic, mean and diastolic blood pressures were decreased after magnesium lithospermate B administration, whereas the urinary levels of kallikrein, prostaglandin E 2 , sodium and potassium were increased. The mechanisms of the depressor action of magnesium lithospermate B were discussed on the basis of these findings