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Storage time of platelet concentrates and risk of a positive blood culture: a nationwide cohort study
- Source :
- Transfusion. 58:16-24
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- BACKGROUND Concern of transfusion-transmitted bacterial infections has been the major hurdle to extend shelf life of platelet (PLT) concentrates. We aimed to investigate the association between storage time and risk of positive blood cultures at different times after transfusion. STUDY DESIGN AND METHODS We performed a nationwide cohort study among PLT transfusion recipients in Denmark between 2010 and 2012, as recorded in the Scandinavian Donations and Transfusions (SCANDAT2) database. Linking with a nationwide database on blood cultures (MiBa), we compared the incidence of a positive blood culture among recipients of PLTs stored 6 to 7 days (old) to those receiving fresh PLTs (1-5 days), using Poisson regression models. We considered cumulative exposures in windows of 1, 3, 5, and 7 days. RESULTS A total of 9776 patients received 66,101 PLT transfusions. The incidence rate ratio (IRR) of a positive blood culture the day after transfusion of at least one old PLT concentrate was 0.77 (95% confidence interval [CI], 0.54-1.09) compared to transfusion of fresh PLT concentrates. The incidence rate of a positive blood culture was lower the day after receiving one old compared to one fresh PLT concentrate (IRR, 0.57; 95% CI, 0.37-0.87). Three, 5, or 7 days after transfusion, storage time was not associated with the risk of a positive blood culture. CONCLUSION Storage of buffy coat-derived PLT concentrates in PAS-C up to 7 days seems safe regarding the risk of a positive blood culture. If anything, transfusion of a single old PLT concentrate may decrease this risk the following day.
- Subjects :
- medicine.medical_specialty
business.industry
Incidence (epidemiology)
Immunology
Hematology
030204 cardiovascular system & hematology
Rate ratio
medicine.disease
Confidence interval
Surgery
03 medical and health sciences
symbols.namesake
0302 clinical medicine
Platelet transfusion
Internal medicine
Bacteremia
medicine
symbols
Immunology and Allergy
Poisson regression
Young adult
business
030215 immunology
Cohort study
Subjects
Details
- ISSN :
- 00411132
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Transfusion
- Accession number :
- edsair.doi...........07334c63923c12e77a335185aea543fb