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Hepatoid adenocarcinoma of the urinary bladder
Hepatoid adenocarcinoma of the urinary bladder
- Source :
- Virchows Archiv. 435:71-75
- Publication Year :
- 1999
- Publisher :
- Springer Science and Business Media LLC, 1999.
-
Abstract
- A new case of hepatoid adenocarcinoma was diagnosed in fragments obtained at transurethral resection (TUR) from a 71-year-old man who had complained of haematuria. The tumour was composed of trabeculae and small solid nests of polygonal atypical cells simulating hepatocarcinoma, together with glandular areas of an otherwise typical adenocarcinoma. Immunohistochemistry showed cytoplasmic reactivity to AFP, AAT, albumin and CAM 5.2. Membrane reactivity was seen in EMA immunostaining, and there was also positivity to polyclonal CEA following a canalicular pattern. Immunoperoxidase studies of hepatocyte growth factor (HGF) and its receptor, c-met, were positive. Their expression may be related to the aggressive behaviour of this tumour.
- Subjects :
- Pathology
medicine.medical_specialty
Urinary bladder
Immunoperoxidase
business.industry
Cell Biology
General Medicine
medicine.disease
digestive system diseases
Pathology and Forensic Medicine
medicine.anatomical_structure
Carcinoma
medicine
Adenocarcinoma
Immunohistochemistry
Hepatocyte growth factor
Alpha-fetoprotein
business
Molecular Biology
Immunostaining
medicine.drug
Subjects
Details
- ISSN :
- 14322307 and 09456317
- Volume :
- 435
- Database :
- OpenAIRE
- Journal :
- Virchows Archiv
- Accession number :
- edsair.doi...........0702f6e80bab866133b2153ed3ad0914
- Full Text :
- https://doi.org/10.1007/s004280050398