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Hepatoid adenocarcinoma of the urinary bladder

Hepatoid adenocarcinoma of the urinary bladder

Authors :
Octavio Burgues
Esther Botella
Samuel Navarro
Jaime Ferrer
Antonio Llombart-Bosch
David Ramos
Source :
Virchows Archiv. 435:71-75
Publication Year :
1999
Publisher :
Springer Science and Business Media LLC, 1999.

Abstract

A new case of hepatoid adenocarcinoma was diagnosed in fragments obtained at transurethral resection (TUR) from a 71-year-old man who had complained of haematuria. The tumour was composed of trabeculae and small solid nests of polygonal atypical cells simulating hepatocarcinoma, together with glandular areas of an otherwise typical adenocarcinoma. Immunohistochemistry showed cytoplasmic reactivity to AFP, AAT, albumin and CAM 5.2. Membrane reactivity was seen in EMA immunostaining, and there was also positivity to polyclonal CEA following a canalicular pattern. Immunoperoxidase studies of hepatocyte growth factor (HGF) and its receptor, c-met, were positive. Their expression may be related to the aggressive behaviour of this tumour.

Details

ISSN :
14322307 and 09456317
Volume :
435
Database :
OpenAIRE
Journal :
Virchows Archiv
Accession number :
edsair.doi...........0702f6e80bab866133b2153ed3ad0914
Full Text :
https://doi.org/10.1007/s004280050398