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Luteolin cocrystals: Characterization, evaluation of solubility, oral bioavailability and theoretical calculation
Luteolin cocrystals: Characterization, evaluation of solubility, oral bioavailability and theoretical calculation
- Source :
- Journal of Drug Delivery Science and Technology. 50:248-254
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Luteolin is an important flavonoid with low water solubility and oral bioavailability properties, which limit its further clinical applications. In the present study, two new cocrystals of luteolin monohydrate with isoniazid and caffeine have been synthesized successfully using liquid assisted grinding method. Solid characterizations including X-ray diffraction, thermal and spectroscopic analysis were carefully performed to identify the two new cocrystals. Temperature-composition phase diagrams for both cocrystals were plotted through differential scanning calorimetry data. The maximum and minimum extreme values of all the compounds on molecular electrostatic potential surfaces that can be converted into hydrogen driving forces were calculated and illustrated. The luteolin-isoniazid cocrystal presents the solubility (112.3 μg mL−1) about three times better than luteolin monohydrate. In the pharmacokinetic analysis, the integrated AUC0-∞ of luteolin-isoniazid and luteolin-caffeine cocrystals performed 2.7 folds and 1.4 folds respectively more enhancements than luteolin monohydrate.
- Subjects :
- Aqueous solution
Materials science
Hydrogen
Pharmaceutical Science
chemistry.chemical_element
02 engineering and technology
021001 nanoscience & nanotechnology
030226 pharmacology & pharmacy
Cocrystal
Bioavailability
Characterization (materials science)
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Differential scanning calorimetry
chemistry
Computational chemistry
Solubility
0210 nano-technology
Luteolin
Subjects
Details
- ISSN :
- 17732247
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- Journal of Drug Delivery Science and Technology
- Accession number :
- edsair.doi...........066e8cd908b5116d52d43dc5fd196f6e
- Full Text :
- https://doi.org/10.1016/j.jddst.2019.02.004