Abstract P323: Urinary Sodium and Potassium Excretion in Relation to Risk of Stroke in Japanese Men and Women: The Circulatory Risk in Communities Study (CIRCS)

Background: Limited evidence is available on the association of urinary sodium and potassium excretion and risk of stroke in population samples of Japanese. Method: A total of 1,403 Japanese men and women aged 40 to 79 years with no history of cardiovascular disease at baseline survey, whose was measured 24-hour urinary excretion of sodium and potassium in the Circulatory Risk in Communities Study (CIRCS). Results: During the median 11.1-years of follow-up, we documented 62 incident strokes and 87 incident cardiovascular disease (stroke and coronary heart disease). The age-adjusted risks of stroke and total cardiovascular disease were higher among persons in the highest tertile of urinary sodium excretion compared with those in the lowest tertile (9.0g/day). These associations did not change substantially after adjusting for cardiovascular risk factors. There were no associations of the urinary potassium excretion with risk of stroke and cardiovascular disease. The respective multivariable hazard ratios (HRs, 95%CI) of stroke and total cardiovascular disease for highest tertile of urinary sodium excretion were 2.06(1.08-3.96) and 1.90(1.09-3.24). For urinary potassium excretion, the corresponding HRs was 1.09(0.51-2.34) and 1.45(0.85-2.49), respectively. Conclusions: Higher excretion of urinary sodium was associated with higher risk of stroke and total cardiovascular disease in general Japanese men and women.